A key component of the Health Delivery Systems Center for Diabetes Translational Research (HDS-CDTR) is its Pilot and Feasibility Program. This program fosters and supports pilot projects in diabetes translational research led by promising early stage investigators at the Center’s sites. The specific aims of this Program are: 1. To support two Pilot and Feasibility studies in each year of the HDS-CDTR renewal; 2. To conduct peer review of Pilot and Feasibility award applications on an annual basis, using the following criteria: overall impact; relevance to diabetes translational research; the promise for leading to an R-level grant submission; relevance to the Center’s Translational Research Cores; and support of the health care delivery system in which they are initiated; 3. To leverage the Pilot and Feasibility awards as a mechanism to support junior investigators in developing robust careers in translational research in diabetes and diabetes prevention.



Title of Project: Provider Experience with Shared Decision Making and Clinical Decision Support Tools with Limited English Proficient Patients with Diabetes and Chronic Kidney Disease: A Qualitative Study
Project Principal Investigator:Pritika Kumar, PhD, Research Investigator, HPIER (Affiliate Faculty)

Project Summary:  
The aim of this project is to use qualitative data to identify the experience of primary care providers (PCP) in using clinical decision support (CDS) with limited English proficient (LEP) patients with diabetes mellitus (DM) or a dual diagnosis of diabetes and chronic kidney disease (CKD), and to identify barriers and facilitators for most effectively using CDS with these patients. The objective of this study is to inform a larger trial in the future on the use of culturally tailored CDS to improve health outcomes for LEP patients.

Title of Project: Perceptions and Preferences Related to Diabetes Prevention Among Individuals with Severe Mental Illness and Metabolic Risk Factors
Project Principal Investigator:Estibaliz Iturralde, PhD, Postdoctoral Fellow, KPNC Division of Research

Project Summary:  
Individuals with severe mental illness (SMI) have double the risk for type 2 diabetes (T2D) and several times higher mortality rates from diabetes-related sequelae, as compared to the general population. One factor explaining this disparity is treatment with atypical antipsychotic medications (AAMs) due to associated weight gain and other metabolic side effects. Clinical trial evidence supports the use of behavioral and pharmacological interventions to mitigate the metabolic risks of these medications, but questions remain regarding how to translate these findings into practice. A critical knowledge gap concerns the perceptions and preferences of people with SMI themselves regarding diabetes prevention. The proposed study will address this gap by gathering qualitative interview data from 40 KPNC adult health system members with SMI and varying degrees of metabolic risk factors. The results of this pilot project will directly contribute to a planned NIDDK proposal to test a new obesity and T2D prevention strategy in our health care delivery system for people with SMI.


Title of Project: Implementation and Effectiveness of Community Diabetes Prevention Programs in the United States 
Project Principal Investigator:Ilya Golovaty, MD, Research Fellow (Affiliate Faculty)

Project Summary:  
This objective of this proposal is to examine implementation and public health impact of community Diabetes Prevention Programs (DPP). We will use the Reach, Effectiveness, Adaptation, Implementation, and Maintenance (RE-AIM) framework to assess DPP uptake in a large cohort of "high risk" adults referred to community DPP across multiple payers and states and to examine public health impact of the DPP program in community practice.

Title of Project: Investigation of Prevalence of and Barriers to Achieving Optimal Glycemic Control among Women with Gestational Diabetes 
Project Principal Investigator:Yeyi Zhu, PhD, Staff Scientist, Kaiser Permanente Northern California (Affiliate Faculty)

Project Summary:  
This pilot project aims to: (1) create a merged database linking glycemic control data and GDM registry data and describe the central tendency characteristics (mean, SD, range, etc.) and frequency of self-monitored capillary glucose data; (2) Compare the percentage of women with GDM achieving optimal glycemic control defined as ≥80% of all capillary glucose measurements meeting target goals (<5.3 mmol/L for fasting and <7.8 mmol/L 1-hour postprandial) by GDM treatment modalities; (3) . Assess the utilization rate of supplemental GDM care resources from the KPNC RPSC (indicated by the number of received/number of scheduled counseling telephone calls) and patient adherence to glucose self-monitoring (total number and frequency of self-monitored glucose measurements) in relation to glycemic control, among women with GDM identified in the KPNC Glucose Tolerance and GDM Registry between 2008 and 2018.

For more information on completed projects, please visit: Pilot and F​easibility_Completed.pdf